Un-Raible Lab

University of Washington

Department of Biological Structure

Why do we use Zebrafish in our Research?

Tools and Techniques

Zebrafish Genetics

	Zebrafish Genomics

		Single Cell Manipulation and Transplants

			Molecular Analysis

Zebrafish Genetics

This genetic map from 1998 shows genes in red, black and purple are genetic markers, and green are mutants. Many more have been added in the years sense this publication.

Single Cell Manipulation

By transplanting single cells or clusters of cells, in early development, latter phenotypes can be rescued.

Single cells or embryos at the single cell stage can also be injected with dyes (for fate mapping), DNA or RNA (for expression), or any number of other materials

Zebrafish Genomics

With the Zebrafish sequencing project nearing completion and existing manipulation techniques like transgenics along with identified genetic mutants and morpholios the zebrafish is a great system for looking at clusters of genes and their control mechanisms.

Molecular Analysis

By injecting molecules of interest in single cells we can study how they effect cell fate. By injecting embryos, at a single cell, a gene of interest with a triggerable promoter we can look at temporal effects of different products.

For a more extensive look at why we use Zebrafish and more about what we do with them, please click here.

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updated 2/22/02T. H. Linbo
Email --tlinbo@u.washington.edu

Un-Raible Lab

University of Washington

Department of Biological Structure

Why do we use Zebrafish in our Research?

Tools and Techniques

Zebrafish Genomics

Single Cell Manipulation and Transplants

Molecular Analysis

Single Cell Manipulation By transplanting single cells or clusters of cells, in early development, latter phenotypes can be rescued. Single cells or embryos at the single cell stage can also be injected with dyes (for fate mapping), DNA or RNA (for expression), or any number of other materials

Zebrafish Genomics With the Zebrafish sequencing project nearing completion and existing manipulation techniques like transgenics along with identified genetic mutants and morpholios the zebrafish is a great system for looking at clusters of genes and their control mechanisms.

Zebrafish Genomics

Molecular Analysis By injecting molecules of interest in single cells we can study how they effect cell fate. By injecting embryos, at a single cell, a gene of interest with a triggerable promoter we can look at temporal effects of different products.

Single Cell Manipulation

By transplanting single cells or clusters of cells, in early development, latter phenotypes can be rescued.

Single cells or embryos at the single cell stage can also be injected with dyes (for fate mapping), DNA or RNA (for expression), or any number of other materials

Zebrafish Genomics

With the Zebrafish sequencing project nearing completion and existing manipulation techniques like transgenics along with identified genetic mutants and morpholios the zebrafish is a great system for looking at clusters of genes and their control mechanisms.

Molecular Analysis

By injecting molecules of interest in single cells we can study how they effect cell fate. By injecting embryos, at a single cell, a gene of interest with a triggerable promoter we can look at temporal effects of different products.