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Neural crest cells start off looking all the same, but they migrate from the dorsal neural tube into the periphery and generate a diverse set of structures. These include neurons and glia that make up the peripheral nervous system, craniofacial cartilage and bone, and pigment cells throughout the body. How do crest cells do this? We think they are influenced by signals from the neural tube and the periphery, as well as through interactions among themselves. These signals are likely to act on regulatory target genes such as nacre. |
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Constructing the Peripheral Nervous System
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| Neurons of the peripheral nervous system are formed from two separate sources: the neural crest and the ectodermal placodes. How do neural crest cells and placode cells interact? In contrast to the neural crest, little is known about how placodes form. What are the signals that induce them? |
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