{"id":8922,"date":"2015-02-25T16:52:27","date_gmt":"2015-02-26T00:52:27","guid":{"rendered":"http:\/\/sop.washington.edu\/?p=8922"},"modified":"2026-05-19T13:57:55","modified_gmt":"2026-05-19T20:57:55","slug":"uw-porpp-fred-hutch-researchers-receive-7-75m-pcori-award-study-cancer-treatment","status":"publish","type":"post","link":"https:\/\/staff.washington.edu\/twentzel\/wordpress\/uw-porpp-fred-hutch-researchers-receive-7-75m-pcori-award-study-cancer-treatment\/","title":{"rendered":"UW PORPP and Fred Hutch Researchers Receive $7.75M PCORI Award to Study Cancer Treatment"},"content":{"rendered":"<figure id=\"attachment_8923\" aria-describedby=\"caption-attachment-8923\" style=\"width: 628px\" class=\"figure figure-caption wp-caption aligncenter\"><a href=\"http:\/\/sop.washington.edu\/wp-content\/uploads\/Neutrophil-Granulocytes_ThinkStock_GettyImages_174105774.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-8923\" src=\"http:\/\/sop.washington.edu\/wp-content\/uploads\/Neutrophil-Granulocytes_ThinkStock_GettyImages_174105774-300x198.jpg\" alt=\"Image of Electron Microscopy of Human Neutrophils\" width=\"628\" height=\"413\" srcset=\"https:\/\/staff.washington.edu\/twentzel\/wordpress\/wp-content\/uploads\/Neutrophil-Granulocytes_ThinkStock_GettyImages_174105774-300x198.jpg 300w, https:\/\/staff.washington.edu\/twentzel\/wordpress\/wp-content\/uploads\/Neutrophil-Granulocytes_ThinkStock_GettyImages_174105774-250x165.jpg 250w, https:\/\/staff.washington.edu\/twentzel\/wordpress\/wp-content\/uploads\/Neutrophil-Granulocytes_ThinkStock_GettyImages_174105774-620x409.jpg 620w\" sizes=\"auto, (max-width: 628px) 100vw, 628px\" \/><\/a><figcaption id=\"caption-attachment-8923\" class=\"wp-caption-text\">Electron Microscopy of Human Neutrophils Credit: ThinkStock <\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<p>A research team, led by Scott Ramsey, director of the Hutchinson Institute for Cancer Outcomes Research (HICOR), that includes UW Department of Pharmacy\u2019s Pharmaceutical Outcomes Research and Policy Program (PORPP) faculty members Sean Sullivan, Jeannine McCune, Aasthaa Bansal, and <a href=\"http:\/\/sop.washington.edu\/new-faculty-join-porpp-med-chem\/\">Gary Lyman<\/a>, who also serves as a co-director at HICOR, has been approved for a $7.75 million, four-year funding award by the Patient-Centered Outcomes Research Institute, or PCORI, an independent, nonprofit organization based in Washington, D.C. The award will be used to conduct a <a href=\"http:\/\/www.pcori.org\/research-results\/2015\/pragmatic-trial-improve-colony-stimulating-factor-use-cancer\">pragmatic clinical trial evaluating the use of colony stimulating factor<\/a>\u00a0to reduce the risk of serious infection in patients undergoing chemotherapy for breast, colorectal or lung cancer.<\/p>\n<p>The study, titled \u201cA Pragmatic Trial to Improve Colony Stimulating Factor Use in Cancer,\u201d is one of five awards totaling $64.1 million approved by PCORI on Tuesday, Feb. 24, that aim to provide patients with information that will help them make better-informed decisions about their care. The result of conducting this important intervention study could lead to improved quality of life for individuals with breast, lung, and colorectal cancer. It is also one of the first studies selected for funding through PCORI\u2019s Pragmatic Clinical Studies Initiative, an effort to produce results that are broadly applicable to a greater variety of patients and care situations and can be more quickly taken up in routine clinical practice.<\/p>\n<p>This work will not only impact the profession of pharmacy, but also provide substantive benefit to cancer patients.\u00a0\u00a0This trial will evaluate if the use of colony stimulating factors, abbreviated CSFs, can be improved by using a clinical guideline-informed approach implemented by pharmacists.\u00a0\u00a0Appropriate use of the CSFs decrease cancer patients&#8217; risk of experiencing low neutrophil, which fight off infection, counts and also decrease how often cancer patients experience a fever and a low neutrophil count (called febrile neutropenia), which can be life threatening.\u00a0\u00a0CSFs are expensive, for the patient and at a national level. Unfortunately, the CSFs\u00a0\u00a0have not been used according to clinical guidelines.\u00a0\u00a0This work seeks to conduct a large-scale pragmatic trial to compare outcomes of the CSFs &#8211; filgrastim and pegfilgrastim &#8211; in cancer patients with select solid tumors, comparing outcomes in those patients receiving CSFs according to the guideline-informed pharmacist-implemented\u00a0system compared to typical clinical practice.<\/p>\n<p>Many clinical studies test whether a treatment works under optimized conditions in specialized research centers, but health care is rarely delivered in such idealized situations and settings. Pragmatic clinical studies test a treatment\u2019s effectiveness in \u201creal-life\u201d practice situations, such as typical hospital and outpatient care settings, and also can include a wider range of study participants, which potentially makes their findings more generally applicable.<\/p>\n<p>\u201cThis project was selected for PCORI funding not only for its scientific merit and commitment to engaging patients and other healthcare stakeholders in a major study conducted in real-world settings, but also for its potential to answer an important question about the use of colony stimulating factors and fill a crucial evidence gap,\u201d said PCORI Executive Director Joe Selby, MD, MPH. \u201cWe look forward to following the study\u2019s progress and working with Fred Hutch and the University of Washington to share the results.\u201d<\/p>\n<p>The HICOR\/PORPP study and the other projects approved for PCORI funding were selected through a highly competitive review process in which patients, caregivers, and other stakeholders joined scientists to evaluate the proposals. Applications were assessed for scientific merit, how well they will engage patients and other stakeholders, and their methodological rigor among other criteria.<\/p>\n<p>Ramsey\u2019s award has been approved pending completion of a business and programmatic review by PCORI staff and issuance of a formal award contract.<\/p>\n<p style=\"text-align: center;\"># # #<\/p>\n<p>The University of Washington School of Pharmacy is committed to educating the next generation of leaders in pharmacy, pharmaceutical research, and healthcare \u2013 while seeking to ensure the safe, rational and cost-effective use of medicines. Founded in 1894, the UW School of Pharmacy is ranked #3 in the world according to Shanghai Jiao Tong University. Follow the School of Pharmacy on <a href=\"http:\/\/www.facebook.com\/UWSOP\">Facebook<\/a> or <a href=\"https:\/\/x.com\/uw_pharmacy\/\">Twitter<\/a>.<\/p>\n<p>PCORI is an independent, nonprofit organization authorized by Congress in 2010. Its mission is to fund research that will provide patients, their caregivers, and clinicians with the evidence-based information needed to make better-informed healthcare decisions. For more information about PCORI\u2019s funding awards, visit the Research and Results page on <a href=\"http:\/\/www.pcori.org\">www.pcori.org<\/a>. <a href=\"http:\/\/www.pcori.org\/funding\/opportunities\">http:\/\/www.pcori.org\/funding\/opportunities<\/a><\/p>\n<p>An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation\u2019s first and largest cancer prevention research program, as well as the clinical coordinating center of the Women\u2019s Health Initiative and the international headquarters of the HIV Vaccine Trials Network.\u00a0For more information visit\u00a0<a href=\"https:\/\/www.fredhutch.org\/en.html\">www.fredhutch.org<\/a>\u00a0or follow Fred Hutch on\u00a0<a href=\"https:\/\/www.facebook.com\/hutchinsoncenter\">Facebook<\/a>,\u00a0<a href=\"https:\/\/x.com\/fredhutch\">Twitter<\/a>\u00a0or\u00a0<a href=\"https:\/\/www.youtube.com\/channel\/UCnWBh22UKMHF4VRKdsQvZqg\">YouTube<\/a>.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; A research team, led by Scott Ramsey, director of the Hutchinson Institute for Cancer Outcomes Research (HICOR), that includes UW Department of Pharmacy\u2019s Pharmaceutical Outcomes Research and Policy Program (PORPP) faculty members Sean Sullivan,&#8230;<\/p>\n","protected":false},"author":3,"featured_media":8923,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[34,31],"tags":[],"class_list":["post-8922","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pharmacy-news","category-sop-news"],"yoast_head":"<!-- This site is optimized with the Yoast 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