{"id":8450,"date":"2005-08-02T09:42:30","date_gmt":"2005-08-02T16:42:30","guid":{"rendered":"http:\/\/sop.washington.edu\/?p=8450"},"modified":"2024-04-02T13:14:19","modified_gmt":"2024-04-02T20:14:19","slug":"uw-professors-identify-genetic-basis-variation-patient-response-warfarin","status":"publish","type":"post","link":"https:\/\/staff.washington.edu\/twentzel\/wordpress\/uw-professors-identify-genetic-basis-variation-patient-response-warfarin\/","title":{"rendered":"UW Professors Identify Genetic Basis for Variation in Patient Response to Warfarin"},"content":{"rendered":"<p><a href=\"http:\/\/sop.washington.edu\/wp-content\/uploads\/warfarin.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright wp-image-8451 size-half\" src=\"http:\/\/sop.washington.edu\/wp-content\/uploads\/warfarin-300x243.jpg\" alt=\"warfarin\" width=\"300\" height=\"243\" srcset=\"https:\/\/staff.washington.edu\/twentzel\/wordpress\/wp-content\/uploads\/warfarin-300x243.jpg 300w, https:\/\/staff.washington.edu\/twentzel\/wordpress\/wp-content\/uploads\/warfarin-250x203.jpg 250w, https:\/\/staff.washington.edu\/twentzel\/wordpress\/wp-content\/uploads\/warfarin.jpg 360w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a>Dr. Allan Rettie, professor and chair of medicinal chemistry in the UW School of Pharmacy, Dr. Mark Rieder, research assistant professor in genomic sciences and their colleagues have identified a major genetic factor responsible for variability in patient responses to the commonly prescribed coumarin-based anticoagulant known as Warfarin. Warfarin, used to prevent harmful clotting after a heart attack, stroke or major surgery, is thought to be taken by over two million people a day in the US alone, yet dosage needs vary considerably between patients resulting in a challenge for their physicians. Rettie and his colleague\u2019s research, supported by NIH funding, in genetic variation and the relationship this has to drug and dosage needs may enable physicians and pharmacists to more precisely medicate, thereby eliminating the negative effects of over- or under-medication. This field of study, known as Pharmacogenetics, is an important scientific pursuit at the forefront of the advancement of medical care. Read more about Rettie\u2019s research in the June 2, issue of <a href=\"http:\/\/content.nejm.org\" target=\"_blank\" rel=\"noopener\">The New England Journal of Medicine<\/a> or click on <a href=\"http:\/\/www.npr.org\/templates\/story\/story.php?storyId=4675941\" target=\"_blank\" rel=\"noopener\">NPR interview<\/a>.<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"\/department-of-medicinal-chemistry\/department-info-2\/department-news\/\">Link to Medicinal Chemistry archived news<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dr. Allan Rettie, professor and chair of medicinal chemistry in the UW School of Pharmacy, Dr. Mark Rieder, research assistant professor in genomic sciences and their colleagues have identified a major genetic factor responsible for&#8230;<\/p>\n","protected":false},"author":3,"featured_media":8451,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[32],"tags":[],"class_list":["post-8450","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medchem-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>UW Professors Identify Genetic Basis for Variation in Patient Response to Warfarin - School of Pharmacy<\/title>\n<meta name=\"description\" content=\"Dr. Allan Rettie, professor and chair of medicinal chemistry in the UW School of Pharmacy, Dr. Mark Rieder, research assistant professor in genomic\" \/>\n<meta name=\"robots\" content=\"index, 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