{"id":32942,"date":"2024-11-18T13:41:18","date_gmt":"2024-11-18T21:41:18","guid":{"rendered":"https:\/\/sop.washington.edu\/?p=32942"},"modified":"2024-11-18T18:00:25","modified_gmt":"2024-11-19T02:00:25","slug":"how-should-we-use-genomics-to-screen-for-risk-of-colon-cancer","status":"publish","type":"post","link":"https:\/\/staff.washington.edu\/twentzel\/wordpress\/how-should-we-use-genomics-to-screen-for-risk-of-colon-cancer\/","title":{"rendered":"How should we use genomics to screen for risk of colon cancer?"},"content":{"rendered":"<figure id=\"attachment_32944\" aria-describedby=\"caption-attachment-32944\" style=\"width: 150px\" class=\"figure figure-caption wp-caption alignleft\"><img decoding=\"async\" src=\"https:\/\/sop.washington.edu\/wp-content\/uploads\/Greg-G-1-1.jpg\" alt=\"Greg Guzauskas, PhD\" width=\"150\" class=\"size-full wp-image-32944 wp-img\" srcset=\"https:\/\/staff.washington.edu\/twentzel\/wordpress\/wp-content\/uploads\/Greg-G-1-1.jpg 336w, https:\/\/staff.washington.edu\/twentzel\/wordpress\/wp-content\/uploads\/Greg-G-1-1-300x420.jpg 300w, https:\/\/staff.washington.edu\/twentzel\/wordpress\/wp-content\/uploads\/Greg-G-1-1-200x280.jpg 200w\" sizes=\"(max-width: 336px) 100vw, 336px\" \/><figcaption id=\"caption-attachment-32944\" class=\"wp-caption-text\">Greg Guzauskas, PhD; Senior Research Scientist, The CHOICE Institute <\/figcaption><\/figure>\n<p>In a new publication in Genetics in Medicine, recent CHOICE graduate Joyce Jiang, PhD, evaluated the cost effectiveness of screening the general population for risk of colon cancer using genomic sequencing.<\/p>\n<figure id=\"attachment_32943\" aria-describedby=\"caption-attachment-32943\" style=\"width: 150px\" class=\"figure figure-caption wp-caption alignright\"><img decoding=\"async\" src=\"https:\/\/sop.washington.edu\/wp-content\/uploads\/Joyce-Jiang.jpg\" alt=\"Joyce Jiang\" width=\"150\" class=\"size-full wp-image-32943 wp-img\" srcset=\"https:\/\/staff.washington.edu\/twentzel\/wordpress\/wp-content\/uploads\/Joyce-Jiang.jpg 350w, https:\/\/staff.washington.edu\/twentzel\/wordpress\/wp-content\/uploads\/Joyce-Jiang-300x420.jpg 300w, https:\/\/staff.washington.edu\/twentzel\/wordpress\/wp-content\/uploads\/Joyce-Jiang-200x280.jpg 200w\" sizes=\"(max-width: 350px) 100vw, 350px\" \/><figcaption id=\"caption-attachment-32943\" class=\"wp-caption-text\">Joyce Jiang, MPH, PhD (\u201924); HEOR PhD Graduate, The CHOICE Institute <\/figcaption><\/figure>\n<p> Dr. Jiang studied two types of genomic risk assessment: one that identifies genomic variation that is common and associated with moderately higher risk (polygenic risk scores, PRS), and another that identifies rare but high-risk variants (Lynch syndrome). Which one should we use? <\/p>\n<figure id=\"attachment_32945\" aria-describedby=\"caption-attachment-32945\" style=\"width: 150px\" class=\"figure figure-caption wp-caption alignleft\"><img decoding=\"async\" src=\"https:\/\/sop.washington.edu\/wp-content\/uploads\/David-Veenstra.jpg\" alt=\"David Veenstra\" width=\"150\" class=\"size-full wp-image-32945 wp-img\" srcset=\"https:\/\/staff.washington.edu\/twentzel\/wordpress\/wp-content\/uploads\/David-Veenstra.jpg 350w, https:\/\/staff.washington.edu\/twentzel\/wordpress\/wp-content\/uploads\/David-Veenstra-300x420.jpg 300w, https:\/\/staff.washington.edu\/twentzel\/wordpress\/wp-content\/uploads\/David-Veenstra-200x280.jpg 200w\" sizes=\"(max-width: 350px) 100vw, 350px\" \/><figcaption id=\"caption-attachment-32945\" class=\"wp-caption-text\">David Veenstra, PharmD, PhD; Professor, The CHOICE Institute <\/figcaption><\/figure>\n<p>Dr. Jiang and colleagues, including PhD advisor David Veenstra, PharmD, PhD, developed a decision analytic model to project long-term clinical and economic outcomes to answer this question. They found that each approach provided clinically meaningful benefits to patients but was only marginally cost effective on their own. Dr. Jiang found that the solution to improving value is to provide both types of genomic screening at the same time! Furthermore, the authors used the model to identify the ideal threshold for identifying patients as PRS \u2018high-risk\u2019: those in the 90th percentile of risk. <\/p>\n<p>These findings will help genomics researchers design more effective and economically valuable genomic screening programs and guide decision makers in the development of clinical guidelines and reimbursement policies.<\/p>\n<p>Publication: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39360752\/\" rel=\"noopener\" target=\"_blank\">https:\/\/pubmed.ncbi.nlm.nih.gov\/39360752\/  <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a new publication in Genetics in Medicine, recent CHOICE graduate Joyce Jiang, PhD, evaluated the cost effectiveness of screening the general population for risk of colon cancer using genomic sequencing. Dr. Jiang studied two&#8230;<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[298],"tags":[],"class_list":["post-32942","post","type-post","status-publish","format-standard","hentry","category-choice-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>How should we use genomics to screen for risk of colon cancer? - School of Pharmacy<\/title>\n<meta name=\"description\" content=\"In a new publication in Genetics in Medicine, recent CHOICE graduate Joyce Jiang, PhD, evaluated the cost effectiveness of screening the general\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/staff.washington.edu\/twentzel\/wordpress\/how-should-we-use-genomics-to-screen-for-risk-of-colon-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"How should we use genomics to screen for risk of colon cancer? 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