{"id":21791,"date":"2019-06-21T13:32:09","date_gmt":"2019-06-21T20:32:09","guid":{"rendered":"https:\/\/sop.washington.edu\/?p=21791"},"modified":"2019-07-02T10:39:40","modified_gmt":"2019-07-02T17:39:40","slug":"harts-research-shows-risk-in-older-adults-with-dementia-taking-cns-active-medications","status":"publish","type":"post","link":"https:\/\/staff.washington.edu\/twentzel\/wordpress\/harts-research-shows-risk-in-older-adults-with-dementia-taking-cns-active-medications\/","title":{"rendered":"Hart\u2019s research shows risk in older adults with dementia taking CNS-active medications"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-15100 alignright\" src=\"https:\/\/sop.washington.edu\/wp-content\/uploads\/hart_laura.jpg\" alt=\"\" width=\"214\" height=\"300\" \/>While competing \u00a0the postdoctoral fellowship in geriatric pharmacy here at the UWSOP, alumna <strong>Laura Hart<\/strong>, PharmD, MS, BCPS, BCGP,\u201914, \u201917, was awarded a research grant by the American College of Clinical Pharmacy (ACCP) Research Institute Futures Grants program. Her research focused on the impact central nervous system (CNS)-active medications have on older adults with dementia. She was particularly interested to see how these medications affect the risk of falls in this population. From that research, she published, \u201cThe Association Between Central Nervous System-Active Medication Use and Fall-Related Injury in Community-Dwelling Older Adults with Dementia,\u201d in the journal, <em>Pharmacotherapy<\/em>.<\/p>\n<p>She and her research team, which includes Plein Center Director <strong>Shelly Gray<\/strong> and Plein Center Assistant Director <strong>Zach Marcum<\/strong>, found that current use of CNS-active medications was associated with an increased risk of fall-related injury, which includes fracture, dislocation, or head injury, even at low doses.<\/p>\n<blockquote>\n<p>\u201cOur results reinforce the importance of cautious use and close monitoring of CNS-active medications in older adults with dementia. It is important for clinicians to address medication use as part of a comprehensive effort to prevent falls, carefully weighing the risks versus benefits of a given medication.\u201d\u2014Laura Hart, PharmD, MS\u201914, \u201917,<\/p>\n<\/blockquote>\n<p>CNS-active medications include antidepressants, anticholinergics, antipsychotics, benzodiazepines, sedatives\/hypnotics, and opioids, and are widely used in populations of older adults, including those with dementia.<\/p>\n<p>The study used data from the\u00a0<a href=\"https:\/\/www.kpwashingtonresearch.org\/our-research\/research-areas\/aging-geriatrics\/act-study-long-running-study-aging-examines-changes-kaiser-permanente-patients-over-time\/\">Adult Changes in Thought (ACT) study<\/a>, which has been following a population of\u00a0<a href=\"https:\/\/wa.kaiserpermanente.org\/\">Kaiser Permanente Washington<\/a>\u00a0patients since 1986. The database is widely regarded as providing a rich source of information for researchers to understand better the impact medications can have on older adults.<\/p>\n<p>Laura sees future research opportunities in measuring the effects of CNS-active medications over time for older adult patients with dementia, as well as evaluating which specific medication classes pose greatest risk.<\/p>\n<h4><\/h4>\n<h4>Are you interested in working with the top-rated faculty and preceptors while studying geriatric pharmacy with\u00a0preeminent student peers?<\/h4>\n<p>Click here for more information about the <a href=\"https:\/\/sop.washington.edu\/plein-center-in-geriatrics\/plein-certificate-in-geriatric-pharmacy\/\" target=\"_blank\" rel=\"noopener noreferrer\">Plein Geriatric Pharmacy Certificate<\/a>\u00a0or click these links to learn about the UW <a href=\"https:\/\/sop.washington.edu\/pharmd\/\" target=\"_blank\" rel=\"noopener noreferrer\">PharmD<\/a> program.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>While competing \u00a0the postdoctoral fellowship in geriatric pharmacy here at the UWSOP, alumna Laura Hart, PharmD, MS, BCPS, BCGP,\u201914, \u201917, was awarded a research grant by the American College of Clinical Pharmacy (ACCP) Research Institute&#8230;<\/p>\n","protected":false},"author":3,"featured_media":15100,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[319],"tags":[],"class_list":["post-21791","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-plein-center-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Hart\u2019s research shows risk in older adults with dementia taking CNS-active medications - School of Pharmacy<\/title>\n<meta name=\"description\" content=\"While competing \u00a0the postdoctoral fellowship in geriatric pharmacy here at the UWSOP, alumna Laura Hart, PharmD, MS, BCPS, BCGP,\u201914, \u201917, was awarded a\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/staff.washington.edu\/twentzel\/wordpress\/harts-research-shows-risk-in-older-adults-with-dementia-taking-cns-active-medications\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hart\u2019s research shows risk in older adults with dementia taking CNS-active medications - School of Pharmacy\" \/>\n<meta property=\"og:description\" content=\"While competing \u00a0the postdoctoral fellowship in geriatric pharmacy here at the UWSOP, alumna Laura Hart, PharmD, MS, BCPS, BCGP,\u201914, \u201917, was awarded a\" \/>\n<meta property=\"og:url\" content=\"https:\/\/staff.washington.edu\/twentzel\/wordpress\/harts-research-shows-risk-in-older-adults-with-dementia-taking-cns-active-medications\/\" \/>\n<meta property=\"og:site_name\" content=\"School of Pharmacy\" \/>\n<meta property=\"article:publisher\" content=\"http:\/\/www.facebook.com\/UWSOP\" \/>\n<meta property=\"article:published_time\" content=\"2019-06-21T20:32:09+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2019-07-02T17:39:40+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/staff.washington.edu\/twentzel\/wordpress\/wp-content\/uploads\/hart_laura.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"214\" \/>\n\t<meta property=\"og:image:height\" content=\"300\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Tim Wentzel\" \/>\n<meta name=\"twitter:card\" 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