{"id":20538,"date":"2018-11-27T14:45:39","date_gmt":"2018-11-27T22:45:39","guid":{"rendered":"https:\/\/sop.washington.edu\/?p=20538"},"modified":"2025-12-04T11:36:45","modified_gmt":"2025-12-04T19:36:45","slug":"zach-marcum-takes-a-multi-prong-approach-toward-developing-a-dementia-prevention-strategy","status":"publish","type":"post","link":"https:\/\/staff.washington.edu\/twentzel\/wordpress\/zach-marcum-takes-a-multi-prong-approach-toward-developing-a-dementia-prevention-strategy\/","title":{"rendered":"Marcum takes a multi-prong approach toward developing a dementia prevention strategy"},"content":{"rendered":"
\"Zach
Zach Marcum, Plein Center Assistant Director of Research and Bailey Faculty Fellow and Assistant Professor of Pharmacy Photo: Alex Levine<\/span><\/figcaption><\/figure>\n

The prospect of developing dementia is terrifying for most people, particularly for those with family members who have had the disease. Many wonder what they can do to prevent the onset of dementia\u2014which is where the research of the Plein Center for Geriatric Pharmacy has some answers.<\/p>\n

Experts know there are healthy habits that will make a difference\u2014exercising regularly, managing heart health, staying intellectually challenged and being connected socially, are among those habits.<\/p>\n

Zach Marcum\u00a0<\/b>surveyed Kaiser Permanente Washington (KPW) members (1661 total) to learn more about their attitudes and beliefs toward health habits and what they could do to ward off the onset of dementia. Of the survey respondents, most believed that it is possible to improve brain health and reduce their risk of dementia, but one-third lacked confidence that they could take action to reduce their risk. Health habits like managing mid-life hypertension, socializing, and keeping the mind sharp with learning, new activities, and exercise make a difference.<\/p>\n

\n

\u201cDementia is not an inevitable part of the aging process. There are steps people can take right now to reduce the risk of the disease\u2014and it\u2019s never too late to start. We are investigating repurposing medications as a dementia prevention strategy.\u201d\u00a0\u2014Zach Marcum, Plein Center Assistant Director of Research and Bailey Faculty Fellow and Assistant Professor of Pharmacy<\/p>\n<\/blockquote>\n

Zach\u2019s study is looking at what the experts say and what the public knows to understand what the gaps are between public and expert knowledge. By understanding the gaps, he anticipates being able to improve public health communications and care recommendations. Additionally, it\u2019s been shown that the earlier Alzheimer\u2019s Disease and related dementias (ADRD) are diagnosed, the better the outcomes are for the patient, making it important to find new ways to detect undiagnosed dementia.<\/p>\n

Using the KPWHRI data, he looked at the historic patterns of chronic medication use in patients who are later diagnosed with dementia, prior to that diagnosis. He found that patients with sub-optimal adherence to taking anti-hypertensives were more likely to develop dementia.<\/p>\n

Moreover, one of the most promising areas for dementia prevention is managing mid-life cardiovascular risk. One such risk factor is cholesterol. Zach is using the KPW data to examine how cholesterol levels from mid-life onward are associated with late-life dementia. He found both low and high levels of non-HDL (\u201cbad cholesterol\u201d) were associated with an increased risk of future dementia. \u201cIt makes sense that high levels of bad cholesterol would increase the risk of dementia,\u201d notes Zach, \u201cbut it\u2019s not as clear why the low levels of bad cholesterol do.\u201d<\/p>\n

In addition, Zach is looking at medications that might be repurposed to ward off or delay the onset of dementia. This approach aims to investigate the repurposing of blood pressure medications as a dementia prevention strategy.<\/p>\n

\u201cLike so many people, I\u2019ve seen first-hand the effect Alzheimer\u2019s disease has on patients and their family members\u2014and that motivates me to find solutions,\u201d said Zach.<\/p>\n

 <\/p>\n

Are you interested in working with the top-rated faculty and\u00a0studying geriatric pharmacy with\u00a0preeminent student peers?<\/h4>\n

Click here for more information about the Plein Geriatric Pharmacy Certificate<\/a>\u00a0or click these links to learn about the UW PharmD<\/a> program.<\/p>\n","protected":false},"excerpt":{"rendered":"

The prospect of developing dementia is terrifying for most people, particularly for those with family members who have had the disease. 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