{"id":20460,"date":"2018-11-27T11:00:44","date_gmt":"2018-11-27T19:00:44","guid":{"rendered":"https:\/\/sop.washington.edu\/?p=20460"},"modified":"2025-12-04T11:36:59","modified_gmt":"2025-12-04T19:36:59","slug":"melissa-barker-haliskis-novel-research-looks-at-the-under-studied-problem-of-epilepsy-in-patients-with-alzheimers","status":"publish","type":"post","link":"https:\/\/staff.washington.edu\/twentzel\/wordpress\/melissa-barker-haliskis-novel-research-looks-at-the-under-studied-problem-of-epilepsy-in-patients-with-alzheimers\/","title":{"rendered":"Barker-Haliski\u2019s novel research looks at the under-studied problem of epilepsy in patients with Alzheimer\u2019s"},"content":{"rendered":"
\"Melissa
Melissa is a neuropharmacologist with a passion for understanding how drugs work in the body. Her research is supported by the UW Royalty Research Fund and the UWSOP Plein Fund Endowment. She works in collaboration with Suman Jayadev, associate professor of neurology at UW Medicine and the clinical core director of UW\u2019s Alzheimer\u2019s Disease Research Center. <\/figcaption><\/figure>\n

People with Alzheimer\u2019s disease can have up to an 87-fold increased risk of seizures. Patients with early-onset Alzheimer\u2019s have the highest risk for seizures, but even patients with \u00a0late onset Alzheimer\u2019s disease\u00a0 are at high risk.<\/p>\n

Despite the risks, little is known about how genes associated with Alzheimer\u2019s disease may affect a person\u2019s susceptibility to seizure across their lifespan. Even less is known about whether anticonvulsant drugs, which, historically, have been tested in young-adult animal models, are effective and well-tolerated in older populations, including those with Alzheimer\u2019s.<\/p>\n

Plein Center researcher Melissa Barker-Haliski<\/strong>hopes to answer this question using preclinical mouse models with Alzheimer\u2019s disease-associated genetic risk factors. Melissa is a neuropharmacologist with expertise in preclinical epilepsy models for anticonvulsant drug discovery. In collaboration with neurogeneticist and UW School of Medicine\u2019s Suman Jayadev, MD, Melissa and her team are investigating how seizures in these preclinical Alzheimer\u2019s disease models age-dependently affect disease trajectory and cognitive outcomes, as well as how anticonvulsant drugs affect seizure control in mice with these Alzheimer\u2019s disease-associated risk genes. Using a mouse model with a mutation in one of the most common early-onset Alzheimer\u2019s disease-associated risk genes (presenilin 2 [PSEN2]), they see how age affects the mice\u2019s susceptibility to seizures and whether those seizures age-dependently respond to available anticonvulsant medications.<\/p>\n

\"Melissa
Melissa Barker-Haliski’s findings suggest that if a patient is having seizures and has an Alzheimer\u2019s diagnosis, anticonvulsant therapies may effectively stop their seizures. <\/figcaption><\/figure>\n

Melissa and her former undergraduate student, Megan Beckman (BS \u201918), will present this research at the Investigator\u2019s Workshop of the 2018 American Epilepsy Society Annual Meeting. Megan received one of 20 highly competitive Young Investigator\u2019s Award from the American Epilepsy Society to offset the costs to present this research work in December in New Orleans, LA. Melissa and Megan\u2019s research shows that many of the approved anticonvulsant medications reduce seizures in aged mice that carry the PSEN2 mutation.<\/p>\n

However, clinical studies in Alzheimer\u2019s disease patients are still needed. This work points to the potential positive impact anticonvulsants have on seizures in adults with Alzheimer\u2019s disease, and also may inform anticonvulsant medication usage in the general population of older adults. As older adults represent the fastest growing patient demographic with epilepsy diagnosis, preclinical and clinical studies of anticonvulsant drugs in these individuals is clearly warranted.<\/p>\n

\n

\u201cAn implication of our findings is that patients with Alzheimer\u2019s disease could benefit if clinicians and neurologists examined their patients early in the disease course to determine if they are experiencing seizures.\u201d\u00a0\u2014Melissa Barker-Haliski, Research Assistant Professor, Pharmacy<\/p>\n<\/blockquote>\n

From a clinical perspective, the good news is Melissa\u2019s preclinical research aligns with the few clinical studies demonstrating that anticonvulsant drugs often work well in older adults, which may indicate their seizures can be controlled. People with Alzheimer\u2019s disease commonly present with seizures that are not the \u201cgrand mal\u201d type with generalized tonic-clonic convulsions. Seizures in older adults are often focal or what\u2019s historically called complex partial seizures\u2014which can seem like a mild stroke or may be called a \u201cspell\u201d\u2014and patients may be disoriented afterward. These seizures can be difficult to distinguish from common symptoms of Alzheimer\u2019s disease, making it challenging for clinicians, patients, and their families to recognize when and if seizures occur, further delaying anticonvulsant use.<\/p>\n

Some anticonvulsant drugs can even impair cognitive function in patients with epilepsy, so their use in people with Alzheimer\u2019s disease is a decision clinicians, patients, and their families should weigh carefully, given their promise to help. Melissa\u2019s work provides preclinical evidence that will inform the clinical studies of seizure control in patients with Alzheimer\u2019s disease. Her ongoing studies within the Plein center support growing recognition in the neurology community that seizures in patients with AD are a common, potentially detrimental, and often under-diagnosed component of the disease.<\/p>\n

Are you interested in working with the top-rated faculty and\u00a0studying geriatric pharmacy with\u00a0preeminent student peers?<\/h4>\n

Click here for more information about the Plein Geriatric Pharmacy Certificate<\/a>\u00a0or click these links to learn about the UW PharmD<\/a> program.<\/p>\n","protected":false},"excerpt":{"rendered":"

People with Alzheimer\u2019s disease can have up to an 87-fold increased risk of seizures. Patients with early-onset Alzheimer\u2019s have the highest risk for seizures, but even patients with \u00a0late onset Alzheimer\u2019s disease\u00a0 are at high…<\/p>\n","protected":false},"author":3,"featured_media":20461,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[34,319],"tags":[],"class_list":["post-20460","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pharmacy-news","category-plein-center-news"],"yoast_head":"\nBarker-Haliski\u2019s novel research looks at the under-studied problem of epilepsy in patients with Alzheimer\u2019s - School of Pharmacy<\/title>\n<meta name=\"description\" content=\"People with Alzheimer\u2019s disease can have up to an 87-fold increased risk of seizures. 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