{"id":19683,"date":"2018-06-13T16:26:37","date_gmt":"2018-06-13T23:26:37","guid":{"rendered":"https:\/\/sop.washington.edu\/?p=19683"},"modified":"2018-06-13T17:39:56","modified_gmt":"2018-06-14T00:39:56","slug":"in-finding-a-different-linking-protein-plotnik-and-hu-lab-open-new-possibilities-for-hiv-therapies-treatments","status":"publish","type":"post","link":"https:\/\/staff.washington.edu\/twentzel\/wordpress\/in-finding-a-different-linking-protein-plotnik-and-hu-lab-open-new-possibilities-for-hiv-therapies-treatments\/","title":{"rendered":"In finding a different linking protein, Plotnik and Hu Lab open new possibilities for HIV therapies & treatments"},"content":{"rendered":"
\"David\u2019s
David\u2019s paper, \u201cExtracellular Matrix Proteins Mediate HIV-1 gp120 interactions with \u03b14\u03b27,\u201d found new insights to HIV and T cell interactions. <\/figcaption><\/figure>\n

Pharmaceutics graduate student David Plotnik<\/b> is first author on a paper published in the Journal of Virology <\/i>with his mentor Shiu-Lok Hu<\/b> as senior author.<\/i> David discovered that the HIV virus does not bind to intestinal T cells the way previously thought.<\/p>\n

Why is that important? HIV causes disease by killing the immune system\u2019s protective T cells, most of which are located in the intestines. When HIV invades the intestines, it destroys intestinal T cells, a loss that plays a major role in the development of AIDS. Finding strategies for protecting intestinal T cells are expected to improve HIV vaccines and therapies.<\/p>\n

Most of the intestinal T cells have a receptor called \u03b14\u03b27 that had been thought to bind to the HIV envelope protein, causing the infection\u2014so this interaction between the receptor and HIV is being investigated as a potential target for therapies and vaccines. David discovered that\u2014contrary to previous reports\u2014the HIV envelope protein does not bind to \u03b14\u03b27.<\/p>\n

There is a different protein, fibronectin (normally found in tissue), that forms a link between the HIV envelope and \u03b14\u03b27. This finding changes the understanding of how intestinal T cells are targeted by HIV, and suggests new therapeutic approaches for protecting these cells.<\/p>\n

This work was supported by the Bill and Melinda Gates Foundation, NIH grant P51 OD010425, the UW Proteomics Resource grant UWPR95794, and Milo Gibaldi Endowment. David was supported by the Pharmaceutical Sciences Training Grant also (T32 GM007750).<\/p>\n

To study with peers in Pharmaceutics like David Plotnik<\/strong> and faculty like Dr. Shiu-Lok Hu<\/strong>, click on the link for\u00a0more information about our\u00a0PhD Program in Pharmaceutics<\/a>.<\/p>\n

Link to Pharmaceutics archived news<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Pharmaceutics graduate student David Plotnik is first author on a paper published in the Journal of Virology with his mentor Shiu-Lok Hu as senior author. 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