{"id":18773,"date":"2017-10-01T20:54:28","date_gmt":"2017-10-02T03:54:28","guid":{"rendered":"https:\/\/sop.washington.edu\/?p=18773"},"modified":"2019-12-10T14:58:39","modified_gmt":"2019-12-10T22:58:39","slug":"physician-and-pharmaceutics-alumnus-john-amory-finds-breakthrough-treatment-for-male-infertility","status":"publish","type":"post","link":"https:\/\/staff.washington.edu\/twentzel\/wordpress\/physician-and-pharmaceutics-alumnus-john-amory-finds-breakthrough-treatment-for-male-infertility\/","title":{"rendered":"John Amory MD, MS, and grad student Faith Stevison find breakthrough treatment for male infertility"},"content":{"rendered":"
\"Dr.
John Amory, M.D., uncovered a remarkable breakthrough for male infertility while pursuing his master’s degree in Pharmaceutics <\/figcaption><\/figure>\n

Infertility can be a physically, emotionally, and financially painful experience for couples wanting to have biologically-related children. If a couple has been unable to conceive naturally in a 12-month period, they are considered infertile. Next steps are typically expensive and painful tests for women to determine the cause of the problem, before a couple pursues assisted reproductive technology such as IVF and IUI.<\/p>\n

But all that may change thanks to newly minted UWSOP alumnus and physician John Amory, \u201917 and his master’s thesis work with Nina Isoherranen<\/b>. Working with graduate student Faith Stevison, the team found a major breakthrough in men\u2019s fertility.<\/p>\n

\"Pharmaceutics
Pharmaceutics graduate student Faith Stevison <\/figcaption><\/figure>\n

Ironically, the breakthrough came from John\u2019s research into a male contraceptive medication.\u00a0After years of researching how to reduce sperm counts, John hypothesized that perhaps there was a way to increase sperm counts. He decided it was time to research in-depth and enrolled in the Pharmaceutics master\u2019s degree program. \u201cIf you are retinoic acid or Vitamin A deficient, male fertility is suppressed,\u201d said Nina. \u201cJohn hypothesized that if he could find a drug to increase intratesticular retinoic acid, it would increase men\u2019s sperm counts and thereby the chance of conception.\u201d<\/p>\n

It turns out there is an FDA-approved drug, Accutane, a prescription acne medication, that is a retinoic acid isomer and increases retinoic acid concentrations and men\u2019s sperm counts.<\/p>\n

For his Pharmaceutics thesis research, John obtained an Investigational New Drug (IND) from the FDA to test his theory that Accutane could be used to treat male infertility by increasing sperm counts. Early results are very promising. From his pilot group of 19 men there are now five babies: three from spontaneous pregnancies and two from assisted conception (one additional pregnancy did not come to term).<\/p>\n

\n

\u201cThe fact that we were able to overcome male infertility for six men in our small sample group, using a medication that is already on the market, shows great promise for couples wishing to conceive.\u201d<\/p>\n

–Dr. John Amory, ’17, M.S., Pharmaceutics alumnus<\/p>\n<\/blockquote>\n

John wants to conduct further research to understand better why this drug intervention did not work for about a third of the patients. \u201cThere are no obvious reasons why it didn\u2019t work in terms of ethnicity, age, weight or other common indicators,\u201d he said, \u201cso I am curious if there are other markers that might explain why.\u201d His research has been accepted for publication and he plans to pursue a double blind placebo study to confirm the pilot test findings.<\/p>\n

John said earning his master\u2019s in Pharmaceutics changed how he practices medicine and thinks about research. \u201cI know a lot more about drug interactions than I did before, even as a seasoned physician. I have a greater appreciation for how hard it is to make a drug and bring it to market. We tend to take medications for granted,\u201d he continued, \u201cbut there is a saying: \u2018the miraculous nature of the mundane.\u2019 To me, the idea you can take something as mundane as a pill and use it to treat a symptom or cure a disease\u2014that\u2019s a miracle.\u201d<\/p>\n

John\u2019s breakthrough findings have the promise of alleviating financial, emotional, and physical stress for many couples wanting to grow their families. If the early pilots bear fruit, the tests and treatment for male infertility could drastically reduce the costs and radically improve outcomes for fertility treatment.<\/p>\n

 <\/p>\n

To study with leaders in Pharmaceutics like Dr. Nina Isoherranen<\/strong>, click on the link for\u00a0more information about our\u00a0PhD Program in Pharmaceutics<\/a>.<\/p>\n

Link to Pharmaceutics archived news<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Infertility can be a physically, emotionally, and financially painful experience for couples wanting to have biologically-related children. If a couple has been unable to conceive naturally in a 12-month period, they are considered infertile. 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