{"id":15033,"date":"2016-08-16T17:20:22","date_gmt":"2016-08-17T00:20:22","guid":{"rendered":"https:\/\/sop.washington.edu\/?p=15033"},"modified":"2026-04-01T13:39:19","modified_gmt":"2026-04-01T20:39:19","slug":"uw-team-finds-key-piece-hiv-drug-effectiveness-puzzle","status":"publish","type":"post","link":"https:\/\/staff.washington.edu\/twentzel\/wordpress\/uw-team-finds-key-piece-hiv-drug-effectiveness-puzzle\/","title":{"rendered":"UW team finds key piece to HIV drug-effectiveness puzzle"},"content":{"rendered":"<figure id=\"attachment_15047\" aria-describedby=\"caption-attachment-15047\" style=\"width: 613px\" class=\"figure figure-caption wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-15047\" src=\"https:\/\/sop.washington.edu\/wp-content\/uploads\/G.vaginalis_0.jpg\" alt=\"Microscopic picture of vaginal epithelial clue cells coated with Gardnerella vaginalis, magnified 400 times.\" width=\"613\" height=\"461\" srcset=\"https:\/\/staff.washington.edu\/twentzel\/wordpress\/wp-content\/uploads\/G.vaginalis_0.jpg 613w, https:\/\/staff.washington.edu\/twentzel\/wordpress\/wp-content\/uploads\/G.vaginalis_0-300x226.jpg 300w, https:\/\/staff.washington.edu\/twentzel\/wordpress\/wp-content\/uploads\/G.vaginalis_0-250x188.jpg 250w, https:\/\/staff.washington.edu\/twentzel\/wordpress\/wp-content\/uploads\/G.vaginalis_0-108x81.jpg 108w\" sizes=\"auto, (max-width: 613px) 100vw, 613px\" \/><figcaption id=\"caption-attachment-15047\" class=\"wp-caption-text\">Microscopic picture of vaginal epithelial clue cells coated with Gardnerella vaginalis, magnified 400 times. <span class=\"wp-media-credit\">Photo: Wikimedia Commons | Dr. F.C. Turner<\/span><\/figcaption><\/figure>\n<h3>Pharmaceutics researchers detect bacteria that counteracts protective drug<\/h3>\n<p>Increasingly, people at risk for HIV infection are turning to preventive drug measures to help stave off the virus. Researchers from the University of Washington School of Pharmacy found that one such drug, Tenofovir, in the form of a topical vaginal gel, is metabolized, or broken down, by the common bacterium\u00a0<em>Gardnerella vaginalis<\/em>.<\/p>\n<p>This negative effect counteracts the gel\u2019s intended protection. Women who apply the drug but who have that bacterium are more vulnerable to HIV infection.<\/p>\n<div class=\"related-story\">The good news, however, is that\u00a0<em>Gardnerella<\/em>, commonly associated with bacterial vaginosis, is relatively easy to detect and treat.<\/div>\n<figure id=\"attachment_15046\" aria-describedby=\"caption-attachment-15046\" style=\"width: 250px\" class=\"figure figure-caption wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"size-sidebar wp-image-15046\" src=\"https:\/\/sop.washington.edu\/wp-content\/uploads\/Klatt-team-250x188.jpg\" alt=\"Nichole Klatt, center, with lab team members Ryan Cheu, left, and Alex Zevin, right.\" width=\"250\" height=\"188\" srcset=\"https:\/\/staff.washington.edu\/twentzel\/wordpress\/wp-content\/uploads\/Klatt-team-250x188.jpg 250w, https:\/\/staff.washington.edu\/twentzel\/wordpress\/wp-content\/uploads\/Klatt-team-108x81.jpg 108w, https:\/\/staff.washington.edu\/twentzel\/wordpress\/wp-content\/uploads\/Klatt-team.jpg 290w\" sizes=\"auto, (max-width: 250px) 100vw, 250px\" \/><figcaption id=\"caption-attachment-15046\" class=\"wp-caption-text\">Nichole Klatt, center, with lab team members Ryan Cheu, left, and Alex Zevin, right. <span class=\"wp-media-credit\">Photo: Alex Levine Photography<\/span><\/figcaption><\/figure>\n<p>The finding emerged in the lab of\u00a0<strong><a href=\"https:\/\/sop.washington.edu\/about\/directory\/name\/nichole-klatt\/\" target=\"_blank\" rel=\"noopener\">Nichole Klatt<\/a><\/strong>, UW assistant professor of pharmaceutics and pathobiology. Grad student Ryan Cheu and postdoctoral fellow Alex Zevin uncovered the mechanism. \u201cThese findings open up a whole new field of research in drug efficacy,\u201d Klatt said.<\/p>\n<p>Their analysis looked at 3,334 genital bacterial proteins from 688 women in the\u00a0<a href=\"http:\/\/www.caprisa.org\/Pages\/Founding\" target=\"_blank\" rel=\"noopener\">Centre for the AIDS Programme of Research in South Africa trial<\/a>. The trial, a collaboration of the UW team and lead investigator Dr. Adam Burgener of the University of Manitoba and Public Health Agency of Canada, assessed the ability of Tenofovir gel to block new HIV infection.<\/p>\n<p>Analysis showed the drug was less effective for a relatively large population of women, and Burgener and Klatt wanted to understand why. In most of the women,\u00a0<em>lactobacillus<\/em>\u00a0was the dominant vaginal bacterium. Burgener discovered that women who have a predominance of \u201cgood\u201d\u00a0<em>lactobacillus<\/em>\u00a0in their reproductive tract were better protected by the Tenofovir gel but hadn\u2019t figured out why until Klatt\u2019s team identified\u00a0<em>Gardnerella<\/em>\u2019s role.<\/p>\n<p>Read more:\u00a0<a href=\"http:\/\/hsnewsbeat.uw.edu\/story\/uw-team-finds-key-piece-hiv-drug-effectiveness-puzzle\" target=\"_blank\" rel=\"noopener\">UW team finds key piece to HIV drug-effectiveness puzzle:\u00a0Pharmacy researchers detect bacteria that counteracts protective drug<\/a><\/p>\n<p><a href=\"https:\/\/sop.washington.edu\/department-of-pharmaceutics\/phd-program\/\">Interested in studying with preeminent faculty like Dr. Klatt? Apply for an MS or PhD in Pharmaceutics? Click here.<\/a><\/p>\n<div>\n<p><a href=\"https:\/\/sop.washington.edu\/department-of-pharmaceutics\/department-news-2\/\">Link to Pharmaceutics archived news<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Pharmaceutics researchers detect bacteria that counteracts protective drug Increasingly, people at risk for HIV infection are turning to preventive drug measures to help stave off the virus. Researchers from the University of Washington School of&#8230;<\/p>\n","protected":false},"author":3,"featured_media":15721,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[33,31],"tags":[227,82,228],"class_list":["post-15033","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pceut-news","category-sop-news","tag-bacteria","tag-hiv","tag-prep"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>UW team finds key piece to HIV drug-effectiveness puzzle - School of Pharmacy<\/title>\n<meta name=\"description\" content=\"Pharmaceutics researchers detect bacteria that counteracts protective drug Increasingly, people at risk 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