{"id":11155,"date":"2015-10-12T15:24:32","date_gmt":"2015-10-12T22:24:32","guid":{"rendered":"http:\/\/sop.washington.edu\/?p=11155"},"modified":"2017-01-04T15:44:11","modified_gmt":"2017-01-04T23:44:11","slug":"rettie-seeds-the-future-of-precision-medicine","status":"publish","type":"post","link":"https:\/\/staff.washington.edu\/twentzel\/wordpress\/rettie-seeds-the-future-of-precision-medicine\/","title":{"rendered":"Rettie Seeds the Future of Precision Medicine"},"content":{"rendered":"
\"The<\/a>
The Rettie Lab team in the Mass Spectrometry Center. From L to R: MedChem grad students John Kowalski and Amanda Johnson, Professor Allan Rettie, and Senior Fellow Sutapa Ray. (Missing: Matt McDonald, Research Scientist) Photo: Alex Levine Photography<\/span><\/figcaption><\/figure>\n

\u201cIt\u2019s a micro-farm,\u201d said Allan Rettie recently, talking of the home where he and his wife, Shannon, nurture a menagerie of creatures great and small. \u201cIf I was not doing science, I might have been a farmer\u201d he said tongue-in-cheek. But it\u2019s impossible to imagine Rettie \u201cnot doing science.\u201d For 30 years he has been at the forefront of what\u2019s happening in drug metabolism and drug interactions. And now he wants to quantify the impact of variants in your genes.<\/p>\n

Rettie came to Medicinal Chemistry as a postdoc in 1985, joined the faculty in 1987, and became department chair in 2000. He serves on the editorial boards of scientific journals, NIH grant review panels, and organizations like the International Society for the Study of Xenobiotics. He teaches classes on drug metabolism and organic medicinal agents and runs an expanding research group that has its roots in drug metabolism.<\/p>\n

\"Rettie<\/a>
Rettie and grad student Amanda Johnson in the Mass Spectrometry Center Photo: Alex Levine Photography<\/span><\/figcaption><\/figure>\n

“We plan to create an encyclopedia of gene variations in important drug-metabolizing enzymes that affect drug responses and make it available to the clinical community in an easily accessible format.”
\n–Allan Rettie<\/h4>\n

Rettie is currently focused on examining the role genetics plays in drug response, a field called Pharmacogenomics. Some people carry potentially harmful gene variants, and for these people an average drug dose can pose significant health risks.<\/p>\n

Consider the commonly prescribed drug warfarin, a \u201cblood thinner\u201d used to treat heart patients and others. The wrong dosage can have a number of negative effects, like excessive bleeding, with disastrous results for patients. Understanding how drug metabolism genes affect the response to warfarin can help health care providers target the dose specifically to individual patients. However, there is currently no easy way for clinicians to know how new gene variants affect treatment with warfarin and other drugs with low safety margins.<\/p>\n

With their latest NIH grant, Rettie; Doug Fowler; and colleagues in the UW Department of Genome Sciences aim to create a comprehensive database of drug-metabolizing enzyme variants that affect a patient\u2019s reaction to commonly used drugs. The project, called Functionalization of Variants in Clinically Actionable Pharmacogenes (F-CAP), will catalog the functional effects of all amino acid variation for five important pharmacogenes during the three-year grant period and make the data available to the clinical community in an easily accessible format. \u201cIt\u2019s quite ambitious, but we are capitalizing on new, high-throughput experimental approaches that should help us reach the target,\u201d Rettie said.<\/p>\n

Perhaps it\u2019s the farmer in Rettie that inclines him to look ahead, even as he grows F-CAP. He is also working on a \u2018suicide gene\u2019 system for personalized T-cell applications in cancer therapy. \u201cCollaborators in Germany provide the immunology expertise while we focus on the drug metabolism side of the project.\u201d Finally, Rettie is interested in the genetics of people in historically isolated and underserved populations. \u201cEveryone should be given the opportunity to be included in the precision medicine revolution.\u201d<\/p>\n

–Caryl Corsi<\/em><\/p>\n

Want to study Medicinal Chemistry with researchers like Allan Rettie? Click here to learn about MedChem and to apply<\/a><\/p>\n

Link to Medicinal Chemistry archived news<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\u201cIt\u2019s a micro-farm,\u201d said Allan Rettie recently, talking of the home where he and his wife, Shannon, nurture a menagerie of creatures great and small. \u201cIf I was not doing science, I might have been…<\/p>\n","protected":false},"author":3,"featured_media":11156,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[32,31],"tags":[96,94],"class_list":["post-11155","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medchem-news","category-sop-news","tag-mass-spec","tag-medchem"],"yoast_head":"\nRettie Seeds the Future of Precision Medicine - School of Pharmacy<\/title>\n<meta name=\"description\" content=\"\u201cIt\u2019s a micro-farm,\u201d said Allan Rettie recently, talking of the home where he and his wife, Shannon, nurture a menagerie of creatures great and small. \u201cIf\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/staff.washington.edu\/twentzel\/wordpress\/rettie-seeds-the-future-of-precision-medicine\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Rettie Seeds the Future of Precision Medicine - 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