{"id":947,"date":"2014-06-18T08:09:10","date_gmt":"2014-06-18T15:09:10","guid":{"rendered":"http:\/\/sop.washington.edu\/?page_id=947"},"modified":"2024-10-23T13:19:37","modified_gmt":"2024-10-23T20:19:37","slug":"instruments","status":"publish","type":"page","link":"https:\/\/staff.washington.edu\/twentzel\/wordpress\/department-of-medicinal-chemistry\/research\/mass-spectrometry-center\/instruments\/","title":{"rendered":"Instruments"},"content":{"rendered":"

The School of Pharmacy Mass Spectrometry Center is home to 12 mass spectrometers and LCs that are available for use by students, staff, faculty and outside users.<\/p>\n

High Resolution \/ High Mass Accuracy Instruments:<\/h3>\n
\n
<\/span>AB Sciex 5600 TOF<\/div>\n
\n
\n
\n

AB Sciex 5600 TOF<\/strong><\/p>\n

The TripleTOF 5600+ System is an innovation in LC-MS\/MS performance that uniquely integrates comprehensive, qualitative exploration, rapid profiling, and high-resolution quantitation workflows on a single platform. It combines high-sensitivity detection, high resolution with the fast acquisition speeds, and stable mass accuracy over days of acquisition. Predominate use is for intact mass analysis of proteins.<\/p>\n

Link to AB Sciex 5600 TOF<\/a><\/p>\n<\/div>\n

\"\"<\/div>\n<\/div>\n<\/div>\n<\/div>\n
\n
<\/span>Bruker TimsTOF Pro<\/div>\n
\n

Bruker TimsTOF Pro<\/strong><\/p>\n

The TimsTOF FleX, powered by the latest parallel accumulation serial fragmentation (PASEF\u00ae<\/sup>) technology, paves the way for 4D-Multiomics applications. The TimsTOF FleX is a fully functional high speed, high sensitivity ESI instrument for all your Omics analyses with integrated MALDI source for fast MALDI Imaging.\u00a0 Proven robustness, high sensitivity and fast MS\/MS acquisition.\u00a0 TimsTOF FleX is the platform of choice for tissue imaging, Proteomic, Metabolomics and 4D-Lipidomics.\u00a0 Predominately used for MALDI tissue imaging.<\/u><\/u><\/p>\n

Link to TimsTOF<\/a><\/p>\n<\/div>\n<\/div>\n

\n
<\/span>Thermo Ascend Tribrid<\/div>\n
\n

Thermo Ascend<\/strong>\u2122 Tribrid\u2122<\/strong><\/p>\n

Thermo Scientific\u2122 Orbitrap\u2122 Ascend Tribrid\u2122 mass spectrometer delivers ultimate throughput and versatility for multiplexed quantitative proteomics and native protein characterization. Characterize the largest biopharmaceuticals with a mass range up to m\/z 16,000.\u00a0 Predominate use is for peptide mapping and structural elucidation.<\/p>\n

Link to Ascend<\/a><\/p>\n<\/div>\n<\/div>\n

\n
<\/span>Thermo Eclipse Tribrid<\/div>\n
\n

Thermo Eclipse\u2122 Tribrid\u2122<\/strong><\/p>\n

The Thermo Scientific Orbitrap Eclipse mass spectrometer incorporates the latest inventions in ion transmission and control, extended\u00a0m\/z<\/em>\u00a0range, and real-time decision making to expand the breadth of your work and push your science beyond today’s discovery. This system is ideally suited for proteomics, structural biology, small-molecule, and biopharmaceutical characterization experiments.\u00a0Predominate use is for peptide mapping and structural elucidation.<\/p>\n

Link to Eclipse<\/a><\/p>\n<\/div>\n<\/div>\n

\n
<\/span>Waters Synapt - G2-Si<\/div>\n
\n

Waters Synapt G2-Si:<\/strong><\/p>\n

SYNAPT G2-Si enables extensive characterization of complex mixtures and molecules with uncompromising qualitative and quantitative performance, streamlined workflows and unparalleled platform versatility. Ion mobility allows for additional separation and identification in complex mixtures.\u00a0 Perfect for MetID experiments, HDX experiments, intact mass and accurate mass for small molecules.\u00a0 Predominate use is for HDX experiments.<\/p>\n

Link to Synapt G2-Si<\/a><\/p>\n<\/div>\n<\/div>\n

\n
<\/span>Waters Synapt XS<\/div>\n
\n
\n

Waters Synapt XS<\/strong><\/p>\n

SYNAPT XS enables extensive characterization of complex mixtures and molecules with uncompromising qualitative and quantitative performance, streamlined workflows and unparalleled platform versatility. Ion mobility allows for additional separation and identification in complex mixtures.\u00a0 Perfect for MetID experiments, HDX experiments, intact mass and accurate mass for small molecules. Predominate use is for lipidomic experiments.<\/p>\n

Link to Synapt XS<\/a><\/p>\n

\"Waters_Synapt_G2_HDX_QTOF\"<\/div>\n<\/div>\n<\/div>\n<\/div>\n

Triple Quad Instruments:<\/h3>\n
\n
<\/span>Waters Xevo TQ-S<\/div>\n
\n
\n
\n

Waters Xevo TQ-S<\/strong><\/p>\n

Waters Xevo TQ-S mass spectrometer designed for the most demanding quantitative UPLC-MS\/MS applications. The tandem quadrupole performance allows you to achieve unrivalled sensitivity and robustness.\u00a0 Predominate use is for targeted quantitative analysis, specifically pharmaceutical pharmacokinetic studies.<\/p>\n

Link to Xevo TQ-S<\/a><\/p>\n<\/div>\n

\"Waters_Xevo_TQ-S\"<\/div>\n<\/div>\n<\/div>\n<\/div>\n
\n
<\/span>Waters Xevo XS<\/div>\n
\n

Waters Xevo XS<\/strong><\/p>\n

Waters Xevo XS mass spectrometer, the most sensitive tandem quadrupole available in the Center.\u00a0 It is designed for the most demanding quantitative UPLC-MS\/MS applications. The ultimate in tandem quadrupole performance allows you to achieve unrivalled sensitivity and robustness.\u00a0 Predominate use is for targeted quantitative analysis, targeted peptide quantitation, pharmacokinetic studies, and residue studies for pesticides and harmful substances.<\/p>\n

Link to Xevo XS<\/a><\/p>\n<\/div>\n<\/div>\n

MALDI, GC and UV\/Vis Fraction Collector:<\/h3>\n
\n
<\/span>Bruker Biotyper<\/div>\n
\n
\n
\n

Bruker Biotyper<\/strong><\/p>\n

The MALDI Biotyper\u00a0(MBT) is a microbial identification system based on Matrix-Assisted Laser Desorption\/Ionization Time-Of-Flight Mass Spectrometry (MALDI-TOF MS), allowing unbiased identification of microorganisms within a few minutes down to the species level. The\u00a0MALDI Biotyper\u00ae<\/sup>\u00a0is an easy, rapid, robust, high-throughput, cost-effective and efficient identification technology.\u00a0 Predominately used for Bacterial ID, polymer analysis and peptide\/protein analysis.<\/p>\n

Link to Biotyper<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

\n
<\/span>Bruker TimsTOF FleX with mirogrid<\/div>\n
\n
\n
\n

Bruker TimsTOF FleX with mirogrid<\/strong><\/p>\n

The TimsTOF FleX, powered by the latest parallel accumulation serial fragmentation (PASEF\u00ae<\/sup>) technology, paves the way for 4D-Multiomics applications. The TimsTOF FleX is a fully functional high speed, high sensitivity ESI instrument for all your Omics analyses with integrated MALDI source for fast MALDI Imaging.\u00a0 Proven robustness, high sensitivity and fast MS\/MS acquisition. \u00a0TimsTOF FleX is the platform of choice for tissue imaging, Proteomic, Metabolomics and 4D-Lipidomics.\u00a0 Predominately used for MALDI tissue imaging.<\/p>\n

Link to TimsTOF<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

\n
<\/span>UV\/Vis DAD With Fraction Collector<\/div>\n
\n
1290 Agilent Infinity UPLC Stack<\/div>\n
Agilent 1260 Fraction Collector<\/div>\n
Agilent DAD UV\/Vis Detector<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

The School of Pharmacy Mass Spectrometry Center is home to 12 mass spectrometers and LCs that are available for use by students, staff, faculty and outside users. 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