{"id":905,"date":"2014-06-17T07:16:39","date_gmt":"2014-06-17T14:16:39","guid":{"rendered":"http:\/\/sop.washington.edu\/?page_id=905"},"modified":"2022-04-22T12:58:46","modified_gmt":"2022-04-22T19:58:46","slug":"publications","status":"publish","type":"page","link":"https:\/\/staff.washington.edu\/twentzel\/wordpress\/department-of-pharmaceutics\/research\/program-on-pharmacokinetics-of-drugs-of-abuse-during-pregnancy-uwpkdap\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

Anoshchenko O, Storelli F, Unadkat JD. <\/strong><\/p>\n

Successful Prediction of Human Fetal Exposure to P-Glycoprotein Substrate Drugs Using the Proteomics-Informed Relative Expression Factor Approach and PBPK Modeling and Simulation. Drug Metab Dispos. 2021 Oct;49(10):919-928. doi: 10.1124\/dmd.121.000538. Epub 2021 Aug 23. PMID: 34426410; PMCID: PMC8626637.<\/p>\n

Anoshchenko O, Milad MA, Unadkat JD. <\/strong><\/p>\n

Estimating fetal exposure to the P-gp substrates, corticosteroids, by PBPK modeling to inform prevention of neonatal respiratory distress syndrome. CPT Pharmacometrics Syst Pharmacol. 2021 Sep;10(9):1057-1070. doi: 10.1002\/psp4.12674. Epub 2021 Jul 23. PMID: 34273255; PMCID: PMC8452292.<\/p>\n

Fay EE, Czuba LC, Sager JE, Shum S, Stephenson-Famy A, Isoherranen N.<\/strong><\/p>\n

Pregnancy Has No Clinically Significant Effect on the Pharmacokinetics of Bupropion or Its Metabolites. Ther Drug Monit. 2021 Dec 1;43(6):780-788. doi: 10.1097\/FTD.0000000000000885. PMID: 33814540; PMCID: PMC8426418.<\/p>\n

Peng J, Ladumor MK, Unadkat JD. <\/strong><\/p>\n

Prediction of Pregnancy-Induced Changes in Secretory and Total Renal Clearance of Drugs Transported by Organic Anion Transporters. Drug Metab Dispos. 2021 Oct;49(10):929-937. doi: 10.1124\/dmd.121.000557. Epub 2021 Jul 27. PMID: 34315779; PMCID: PMC8626639.<\/p>\n

Shum S, Shen DD, Isoherranen N. <\/strong><\/p>\n

Predicting Maternal-Fetal Disposition of Fentanyl Following Intravenous and Epidural Administration Using Physiologically Based Pharmacokinetic Modeling. Drug Metab Dispos. 2021 Nov;49(11):1003-1015. doi: 10.1124\/dmd.121.000612. Epub 2021 Aug 18. PMID: 34407992.<\/p>\n

Chen X, Unadkat JD, Mao Q.<\/strong><\/p>\n

Tetrahydrocannabinol and Its Major Metabolites Are Not (or Are Poor) Substrates or Inhibitors of Human P-Glycoprotein [ATP-Binding Cassette (ABC) B1] and Breast Cancer Resistance Protein (ABCG2). Drug Metab Dispos. 2021 Oct;49(10):910-918. doi: 10.1124\/dmd.121.000505. Epub 2021 Jul 29. PMID: 34326138; PMCID: PMC8626638.<\/p>\n

Patilea-Vrana GI, Unadkat JD. <\/strong><\/p>\n

Development and Verification of a Linked \u03949-THC\/11-OH-THC Physiologically Based Pharmacokinetic Model in Healthy, Nonpregnant Population and Extrapolation to Pregnant Women. Drug Metab Dispos. 2021 Jul;49(7):509-520. doi: 10.1124\/dmd.120.000322. Epub 2021 May 5. PMID: 33952608; PMCID: PMC8313051.<\/p>\n

Cox EJ, Tian DD, Clarke JD, Rettie AE, Unadkat JD, Thummel KE, McCune JS, Paine MF. <\/strong><\/p>\n

Modeling Pharmacokinetic Natural Product-Drug Interactions for Decision-Making: A NaPDI Center Recommended Approach. Pharmacol Rev. 2021 Apr;73(2):847-859. doi: 10.1124\/pharmrev.120.000106. PMID: 33712517; PMCID: PMC7956993.<\/p>\n

Imaoka T, Huang W, Shum S, Hailey DW, Chang SY, Chapron A, Yeung CK, Himmelfarb J, Isoherranen N, Kelly EJ.<\/strong><\/p>\n

Bridging the gap between in silico and in vivo by modeling opioid disposition in a kidney proximal tubule microphysiological system. Sci Rep. 2021 Nov 1;11(1):21356. doi: 10.1038\/s41598-021-00338-y. PMID: 34725352; PMCID: PMC8560754.<\/p>\n

Shum S, Isoherranen N. <\/strong><\/p>\n

Human Fetal Liver Metabolism of Oxycodone Is Mediated by CYP3A7. AAPS J. 2021 Jan 12;23(1):24. doi: 10.1208\/s12248-020-00537-x. PMID: 33438174; PMCID: PMC8106324.<\/p>\n

Han LW, Wang L, Shi Y, Dempsey JL, Pershutkina OV, Dutta M, Bammler TK, Cui JY, Mao Q.<\/strong><\/p>\n

Impact of Microbiome on Hepatic Metabolizing Enzymes and Transporters in Mice during Pregnancy. Drug Metab Dispos. 2020 Aug;48(8):708-722. doi: 10.1124\/dmd.120.000039. Epub 2020 Jun 4. PMID: 32499338; PMCID: PMC7434050.<\/p>\n

Huang W, Isoherranen N. <\/strong><\/p>\n

Novel Mechanistic PBPK Model to Predict Renal Clearance in Varying Stages of CKD by Incorporating Tubular Adaptation and Dynamic Passive Reabsorption. CPT Pharmacometrics Syst Pharmacol. 2020 Oct;9(10):571-583. doi: 10.1002\/psp4.12553. Epub 2020 Sep 25. PMID: 32977369; PMCID: PMC7577018.<\/p>\n

Bansal S, Maharao N, Paine MF, Unadkat JD<\/strong>.<\/p>\n

Predicting the Potential for Cannabinoids to Precipitate Pharmacokinetic Drug Interactions via Reversible Inhibition or Inactivation of Major Cytochromes P450. Drug Metab Dispos. 2020 Oct;48(10):1008-1017. doi: 10.1124\/dmd.120.000073. Epub 2020 Jun 25. PMID: 32587099; PMCID: PMC7543485.<\/p>\n

Anoshchenko O, Prasad B, Neradugomma NK, Wang J, Mao Q, Unadkat JD. <\/strong><\/p>\n

Gestational Age-Dependent Abundance of Human Placental Transporters as Determined by Quantitative Targeted Proteomics. Drug Metab Dispos. 2020 Sep;48(9):735-741. doi: 10.1124\/dmd.120.000067. Epub 2020 Jun 26. Erratum in: Drug Metab Dispos. 2020 Dec;48(12):1347. PMID: 32591415; PMCID: PMC7469251.<\/p>\n

Han LW, Shi Y, Paquette A, Wang L, Bammler TK, Mao Q. <\/strong><\/p>\n

Key hepatic metabolic pathways are altered in germ-free mice during pregnancy. PLoS One. 2021 Mar 12;16(3):e0248351. doi: 10.1371\/journal.pone.0248351. PMID: 33711049; PMCID: PMC7954286.<\/p>\n

Huang W, Czuba LC, Manuzak JA, Martin JN, Hunt PW, Klatt NR, Isoherranen N. <\/strong><\/p>\n

Objective Identification of Cannabis Use Levels in Clinical Populations Is Critical for Detecting Pharmacological Outcomes. Cannabis Cannabinoid Res. 2021 Nov 18. doi: 10.1089\/can.2021.0068. Epub ahead of print. PMID: 34793254.<\/p>\n","protected":false},"excerpt":{"rendered":"

Anoshchenko O, Storelli F, Unadkat JD. Successful Prediction of Human Fetal Exposure to P-Glycoprotein Substrate Drugs Using the Proteomics-Informed Relative Expression Factor Approach and PBPK Modeling and Simulation. 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