Bryan Allan Comstock




2009                    University of Washington, Seattle, WA

                           Summer Institute for Statistical Genetics Certificate

2001 – 2004         University of Washington, Seattle, WA

                           Master of Science in Biostatistics

1995 – 1999         Northern Arizona University, Flagstaff, AZ

                           Bachelor of Science in Extended Mathematics - Statistics Emphasis

Employment History


2013 – Present      Center for Biomedical Statistics, University of Washington, Seattle, WA

Senior Biostatistician

o   Develop and support grant applications for extramural funding in the areas of health services research, radiology, neonatology, and nephrology

o   Primary biostatistician for 4 randomized clinical trials and a back pain registry

o   Develop and support electronic data capture systems for multi-site randomized studies


2008 – 2012         Center for Biomedical Statistics, University of Washington, Seattle, WA

Director of Operations, Biostatistician

o   Manage collaborative requests for local NIH CTSA and UW Department of Biostatistics

o   Develop and manage tools, processes, and triage methods of consultation requests

o   Advise on and review methods sections for NIH grant applications and manuscripts

o   Statistical reviewer of 15-20 pilot grant applications annually

o   Supervise collaborative activity of UW Biostatistics PhD graduate student research assistants

o   Primary biostatistician on two randomized clinical trials and two longitudinal cohort studies

o   Develop and support electronic data capture system for a multi-site registry and randomized trial


2004 – 2008         Multidisciplinary Clinical Research Center, University of Washington, Seattle, WA


o   Primary biostatistician on two randomized trials and two cohort studies studying treatments

o   Conducted ad hoc and formal data analyses and wrote methods / results sections of manuscripts

o   Generated biannual data and safety monitoring reports


2001 – 2004         Fred Hutchinson Cancer Research Center, Seattle, WA.

Statistical Research Associate

o   Bayesian analysis of longitudinal CA19-9 biomarker data in patients with pancreatic cancer

o   Data quality reviewer for two large multicenter randomized studies

Graduate Coursework     


Statistical inference and theory, generalized linear models, methods for longitudinal and clustered data, data mining, Bayesian decision theory, survival analysis, clinical trial design, methods of statistical learning, Markov Chain Monte Carlo sampling, methods for multiple comparisons, multiple imputation. Completed all applied UW PhD courses in Biostatistics and all but two theory courses.

Statistical Software


Experienced with: R, Stata, SAS, LaTeX, Office on Macs and PCs. Familiar with: SPSS, JMP, and C.

Awards, Teaching, Services, Committees, Memberships 


2012-present         Statistical reviewer for the journal Radiology

2012                    Dept of Biostatistics Outstanding Staff Award

2011-present         Society of Clinical Trials Member

2011                    Dept of Biostatistics Faculty Staff Relations Committee

2009                    Dept of Biostatistics Outstanding Staff Award

2006                    Health Services lecture on diagnostic testing for UW Radiology residents

2005                    Inducted into NAU Cross Country Hall of Fame

2003 – 2004         Teaching aide for graduate-level UW Biostatistics service courses

2003                    Passed UW Biostatistics PhD Applied Examination

2003                    UW Biostatistics Admissions Committee

1999                    Standard Bearer of NAU Graduation Commencement



1.             Gallego CJ, Bennette CS, Heagerty P, Comstock B, Horike-Pyne M, Hisama F, Amendola LM, Bennett RL, Dorschner MO, Tarczy-Hornoch P, Grady WM, Fullerton SM,  Trinidad SB, Regier DA, Nickerson DA, Burke W, Patrick DL, Jarvik GP, Veenstra DL. Comparative effectiveness of next generation genomic sequencing for disease diagnosis: Design of a randomized controlled trial in patients with colorectal cancer/polyposis syndromes. Contemp Clin Trials. 2014 Jul 3;39(1):1-8. doi: 10.1016/j.cct.2014.06.016. [Epub ahead of print] PubMed PMID: 24997220.

2.             Friedly JL, Comstock BA, Turner JA, Heagerty PJ, Deyo RA, Sullivan SD, Bauer Z, Bresnahan BW, Avins AL, Nedeljkovic SS, Nerenz DR, Standaert C, Kessler L, Akuthota V, Annaswamy T, Chen A, Diehn F, Firtch W, Gerges FJ, Gilligan C, Goldberg H, Kennedy DJ, Mandel S, Tyburski M, Sanders W, Sibell D, Smuck M, Wasan A, Won L, Jarvik JG. A randomized trial of epidural glucocorticoid injections for spinal stenosis. N Engl J Med. 2014 Jul 3;371(1):11-21. doi: 10.1056/NEJMoa1313265. Erratum in: N Engl J Med. 2014 Jul 24;371(4):390. PubMed PMID: 24988555.

3.             Rundell SD, Bresnahan BW, Heagerty PJ, Comstock BA, Friedly JL, Jarvik JG, Sullivan SD. Mapping a Patient-Reported Functional Outcome Measure to a Utility Measure for Comparative Effectiveness and Economic Evaluations in Older Adults with Low Back Pain. Med Decis Making. 2014 May 14. pii: 0272989X14533995. [Epub ahead of print] PubMed PMID: 24829274.

4.             Jarvik JG, Comstock BA, Heagerty PJ, Turner JA, Sullivan SD, Shi X, Nerenz DR, Nedeljkovic SS, Kessler L, James K, Friedly JL, Bresnahan BW, Bauer Z, Avins AL, Deyo RA. Back pain in seniors: the Back pain Outcomes using Longitudinal Data (BOLD) cohort baseline data. BMC Musculoskelet Disord. 2014 Apr 23;15:134. doi:10.1186/1471-2474-15-134. PubMed PMID: 24755158; PubMed Central PMCID: PMC4021204.

5.             Glassman D, White L, Lewis A, King H, Clarke A, Glassman T, Comstock B, Hannaford B, Lendvay TS. Raven surgical robot training in preparation for da vinci. Stud Health Technol Inform. 2014;196:135-41. PubMed PMID: 24732494.

6.             Chen C, White L, Kowalewski T, Aggarwal R, Lintott C, Comstock B, Kuksenok K,  Aragon C, Holst D, Lendvay T. Crowd-Sourced Assessment of Technical Skills: a novel method to evaluate surgical performance. J Surg Res. 2014 Mar;187(1):65-71. doi: 10.1016/j.jss.2013.09.024. Epub 2013 Oct 10. PubMed PMID: 24555877.

7.             Mirza SK, Deyo RA, Heagerty PJ, Turner JA, Martin BI, Comstock BA. One-year outcomes of surgical versus nonsurgical treatments for discogenic back pain: a community-based prospective cohort study. Spine J. 2013 Nov;13(11):1421-33. doi: 10.1016/j.spinee.2013.05.047. Epub 2013 Jul 23. PubMed PMID: 23890947.

8.             McCullough BJ, Comstock BA, Deyo RA, Kreuter W, Jarvik JG. Major medical outcomes with spinal augmentation vs conservative therapy. JAMA Intern Med. 2013 Sep 9;173(16):1514-21. doi: 10.1001/jamainternmed.2013.8725. PubMed PMID:23836009; PubMed Central PMCID: PMC4023124.

9.             Heffner JL, Wyszynski CM, Comstock B, Mercer LD, Bricker J. Overcoming recruitment challenges of web-based interventions for tobacco use: the case of web-based acceptance and commitment therapy for smoking cessation. Addict Behav.  2013 Oct;38(10):2473-6. doi: 10.1016/j.addbeh.2013.05.004. Epub 2013 May 14. PubMed PMID: 23770645; PubMed Central PMCID: PMC3725211.

10.         Bricker J, Wyszynski C, Comstock B, Heffner JL. Pilot randomized controlled trial of web-based acceptance and commitment therapy for smoking cessation. Nicotine Tob Res. 2013 Oct;15(10):1756-64. doi: 10.1093/ntr/ntt056. Epub 2013 May 23. PubMed PMID: 23703730; PubMed Central PMCID: PMC3768336.

11.         Comstock BA, Sitlani CM, Jarvik JG, Heagerty PJ, Turner JA, Kallmes DF. Investigational vertebroplasty safety and efficacy trial (INVEST): patient-reported outcomes through 1 year. Radiology. 2013 Oct;269(1):224-31. doi: 10.1148/radiol.13120821. Epub 2013 May 21. PubMed PMID: 23696683; PubMed Central  PMCID: PMC3781356.

12.         Holman LR, Bricker JB, Comstock BA. Psychological predictors of male smokeless tobacco use initiation and cessation: a 16-year longitudinal study. Addiction. 2013 Jul;108(7):1327-35. doi: 10.1111/add.12164. Epub 2013 Apr 4. PubMed PMID: 23607490; PubMed Central PMCID: PMC3679343.

13.         Heagerty PJ, Comstock BA. Exploration of lagged associations using longitudinal data. Biometrics. 2013 Mar;69(1):197-205. doi: 10.1111/j.1541-0420.2012.01812.x. Epub 2013 Jan 22. PubMed PMID: 23339517; PubMed Central PMCID: PMC3622183.

14.         Hu A, Isetti D, Hillel AD, Waugh P, Comstock B, Meyer TK. Disease-specific self-efficacy in spasmodic dysphonia patients. Otolaryngol Head Neck Surg. 2013 Mar;148(3):450-5. doi: 10.1177/0194599812472319. Epub 2013 Jan 8. PubMed PMID: 23300221.

15.         Kallmes DF, Comstock BA. Commentary: No comparison: conservative management of painful spontaneous osteoporotic compression fractures is the way to go. Spine J. 2012 Nov;12(11):1006-7. doi: 10.1016/j.spinee.2012.09.055. PubMed PMID: 23199408.

16.         Gilmer BB, Comstock BA, Jette JL, Warme WJ, Jackins SE, Matsen FA. The prognosis for improvement in comfort and function after the ream-and-run arthroplasty for glenohumeral arthritis: an analysis of 176 consecutive cases. J  Bone Joint Surg Am. 2012 Jul 18;94(14):e102. doi: 10.2106/JBJS.K.00486. PubMed PMID: 22810409.

17.         Jarvik JG, Comstock BA, Bresnahan BW, Nedeljkovic SS, Nerenz DR, Bauer Z, Avins AL, James K, Turner JA, Heagerty P, Kessler L, Friedly JL, Sullivan SD, Deyo RA. Study protocol: the Back Pain Outcomes using Longitudinal Data (BOLD) registry. BMC Musculoskelet Disord. 2012 May 3;13:64. doi: 10.1186/1471-2474-13-64. PubMed PMID: 22554166; PubMed Central PMCID: PMC3403933.

18.         Friedly JL, Bresnahan BW, Comstock B, Turner JA, Deyo RA, Sullivan SD, Heagerty P, Bauer Z, Nedeljkovic SS, Avins AL, Nerenz D, Jarvik JG. Study protocol- Lumbar Epidural steroid injections for Spinal Stenosis (LESS): a double-blind randomized controlled trial of epidural steroid injections for lumbar spinal stenosis among older adults. BMC Musculoskelet Disord. 2012 Mar 29;13:48. doi: 10.1186/1471-2474-13-48. PubMed PMID: 22458343; PubMed Central PMCID: PMC3349603.

19.         Schimmel-Bristow A, Bricker JB, Comstock B. Can Acceptance & Commitment Therapy be delivered with fidelity as a brief telephone-intervention? Addict Behav. 2012 Apr;37(4):517-20. doi: 10.1016/j.addbeh.2011.11.015. Epub 2011 Nov 17. PubMed PMID: 22192865; PubMed Central PMCID: PMC3718556.

20.         Turner JA, Hollingworth W, Comstock B, Deyo RA. Response to letter from Dr North. Med Care. 2012 Jan;50(1):107-8. doi: 10.1097/MLR.0b013e31820097a9. PubMed PMID: 22052296.

21.         Staples MP, Kallmes DF, Comstock BA, Jarvik JG, Osborne RH, Heagerty PJ, Buchbinder R. Effectiveness of vertebroplasty using individual patient data from two randomised placebo controlled trials: meta-analysis. BMJ. 2011 Jul 12;343:d3952. doi: 10.1136/bmj.d3952. PubMed PMID: 21750078.

22.         Hollingworth W, Turner JA, Welton NJ, Comstock BA, Deyo RA. Costs and Cost-Effectiveness of Spinal Cord Stimulation (SCS) for Failed Back Surgery Syndrome: An Observational Study in a Workers' Compensation Population. Spine (Phila Pa 1976). 2011 Jul 5. PubMed PMID: 21738098.

23.         Bricker JB, Schiff L, Comstock BA. Does Avoidant Coping Influence Young Adults' Smoking?: A Ten-Year Longitudinal Study. Nicotine Tob Res. 2011 May 4. PubMed PMID: 21543547.

24.         Wyszynski CM, Bricker JB, Comstock BA. Parental smoking cessation and child daily smoking: A 9-year longitudinal study of mediation by child cognitions about smoking. Health Psychol. 2011 Mar;30(2):171-6. PubMed PMID: 21401251; PubMed Central PMCID: PMC3064434.

25.         Otten R, Bricker JB, Liu J, Comstock BA, Peterson AV. Adolescent psychological and social predictors of young adult smoking acquisition and cessation: A 10-year longitudinal study. Health Psychol. 2011 Mar;30(2):163-70. PubMed PMID: 21401250.

26.         Weinert C, Cudney S, Comstock B, Bansal A. Computer intervention impact on psychosocial adaptation of rural women with chronic conditions. Nurs Res. 2011 Mar-Apr;60(2):82-91. PubMed PMID: 21358372.

27.         Horvath K, Freeny P, Escallon J, Heagerty P, Comstock B, Glickerman DJ, Bulger E, Sinanan M, Langdale L, Kolokythas O, Andrews RT. Safety and efficacy of video-assisted retroperitoneal debridement for infected pancreatic collections: a multicenter, prospective, single-arm phase 2 study. Arch Surg. 2010 Sep;145(9):817-25. PubMed PMID: 20855750.

28.         Bricker JB, Liu J, Comstock BA, Peterson AV, Kealey KA, Marek PM. Social cognitive mediators of adolescent smoking cessation: results from a large randomized intervention trial. Psychol Addict Behav. 2010 Sep;24(3):436-45. PubMed PMID: 20853929

29.         Brinjikji W, Comstock BA, Heagerty PJ, Jarvik JG, Kallmes DF. Investigational Vertebroplasty Efficacy and Safety Trial: detailed analysis of blinding efficacy. Radiology. 2010 Oct;257(1):219-25. PubMed PMID: 20851942.

30.         Brinjikji W, Comstock BA, Gray L, Kallmes DF. Local Anesthesia with Bupivacaine and Lidocaine for Vertebral Fracture trial (LABEL): a report of outcomes and comparison with the Investigational Vertebroplasty Efficacy and Safety Trial (INVEST). AJNR Am J Neuroradiol. 2010 Oct;31(9):1631-4. Epub 2010 Jun 3. PubMed PMID: 20522567.

31.         Kallmes DF, Jarvik JG, Osborne RH, Comstock BA, Staples MP, Heagerty PJ, Turner JA, Buchbinder R. Clinical utility of vertebroplasty: elevating the evidence. Radiology. 2010 Jun;255(3):675-80. PubMed PMID: 20501706.

32.         Turner JA, Hollingworth W, Comstock B, Deyo RA. Comparative effectiveness research and policy: experiences conducting a coverage with evidence development study of a therapeutic device. Med Care. 2010 Jun;48(6 Suppl):S129-36. PubMed PMID: 20473203.

33.         Turner JA, Hollingworth W, Comstock BA, Deyo RA. A response to Wasan editorial "Spinal cord stimulation in a workers' compensation population: how difficult it can be to interpret a clinical trial": stimulating discussion. Pain. 2010 May;149(2):406-7. PubMed PMID: 20207083.

34.         Turner JA, Hollingworth W, Comstock BA, Deyo RA. Spinal cord stimulation for failed back surgery syndrome: outcomes in a workers' compensation setting. Pain. 2010 Jan;148(1):14-25. Epub 2009 Oct 28. PubMed PMID: 19875232.

35.         Jarvik JG, Comstock BA, Kliot M, Turner JA, Chan L, Heagerty PJ, Hollingworth W, Kerrigan CL, Deyo RA. Surgery versus non-surgical therapy for carpal tunnel syndrome: a randomised parallel-group trial. Lancet. 2009 Sep 26;374(9695):1074-81. PubMed PMID: 19782873.

36.         Martin BI, Turner JA, Mirza SK, Lee MJ, Comstock BA, Deyo RA. Trends in health care expenditures, utilization, and health status among US adults with spine problems, 1997-2006. Spine (Phila Pa 1976). 2009 Sep 1;34(19):2077-84. PubMed PMID: 19675510.

37.         Kallmes DF, Comstock BA, Heagerty PJ, Turner JA, Wilson DJ, Diamond TH, Edwards R, Gray LA, Stout L, Owen S, Hollingworth W, Ghdoke B, Annesley-Williams DJ, Ralston SH, Jarvik JG. A randomized trial of vertebroplasty for osteoporotic spinal fractures. N Engl J Med. 2009 Aug 6;361(6):569-79. PubMed PMID: 19657122;PubMed Central PMCID: PMC2930487.

38.         Relyea-Chew A, Hollingworth W, Chan L, Comstock BA, Overstreet KA, Jarvik JG. Personal bankruptcy after traumatic brain or spinal cord injury: the role of medical debt. Arch Phys Med Rehabil. 2009 Mar;90(3):413-9. PubMed PMID: 19254605.

39.         Jarvik JG, Comstock BA, Heagerty PJ, Haynor DR, Fulton-Kehoe D, Kliot M, Franklin GM. Magnetic resonance imaging compared with electrodiagnostic studies in patients with suspected carpal tunnel syndrome: predicting symptoms, function, and surgical benefit at 1 year. J Neurosurg. 2008 Mar;108(3):541-50. PubMed PMID:18312102.

40.         Martin BI, Deyo RA, Mirza SK, Turner JA, Comstock BA, Hollingworth W, Sullivan SD. Expenditures and health status among adults with back and neck problems. JAMA. 2008 Feb 13;299(6):656-64. Erratum in: JAMA. 2008 Jun 11;299(22):2630. PubMed PMID: 18270354.

41.         Gray LA, Jarvik JG, Heagerty PJ, Hollingworth W, Stout L, Comstock BA, Turner JA, Kallmes DF. INvestigational Vertebroplasty Efficacy and Safety Trial (INVEST): a randomized controlled trial of percutaneous vertebroplasty. BMC Musculoskelet Disord. 2007 Dec 20;8:126. PubMed PMID: 18096050; PubMed Central PMCID: PMC2257946.

42.         Martin BI, Mirza SK, Comstock BA, Gray DT, Kreuter W, Deyo RA. Are lumbar spine reoperation rates falling with greater use of fusion surgery and new surgical technology? Spine (Phila Pa 1976). 2007 Sep 1;32(19):2119-26. PubMed PMID: 17762814.

43.         Hollingworth W, Devine EB, Hansen RN, Lawless NM, Comstock BA, Wilson-Norton JL, Tharp KL, Sullivan SD. The impact of e-prescribing on prescriber and staff time in ambulatory care clinics: a time motion study. J Am Med Inform Assoc. 2007 Nov-Dec;14(6):722-30. Epub 2007 Aug 21. PubMed PMID: 17712088; PubMed Central PMCID: PMC2213487.

44.         Hollingworth W, Relyea-Chew A, Comstock BA, Overstreet JK, Jarvik JG. The risk of bankruptcy before and after brain or spinal cord injury: a glimpse of the iceberg's tip. Med Care. 2007 Aug;45(8):702-11. PubMed PMID: 17667303.

45.         Martin BI, Mirza SK, Comstock BA, Gray DT, Kreuter W, Deyo RA. Reoperation rates following lumbar spine surgery and the influence of spinal fusion procedures. Spine (Phila Pa 1976). 2007 Feb 1;32(3):382-7. PubMed PMID: 17268274.

46.         Chan L, Turner JA, Comstock BA, Levenson LM, Hollingworth W, Heagerty PJ, Kliot M, Jarvik JG. The relationship between electrodiagnostic findings and patient symptoms and function in carpal tunnel syndrome. Arch Phys Med Rehabil. 2007 Jan;88(1):19-24. PubMed PMID: 17207670.

47.         Gray DT, Deyo RA, Kreuter W, Mirza SK, Heagerty PJ, Comstock BA, Chan L. Population-based trends in volumes and rates of ambulatory lumbar spine surgery. Spine (Phila Pa 1976). 2006 Aug 1;31(17):1957-63; discussion 1964. PubMed PMID:16924213.

48.         Hollingworth W, Medina LS, Lenkinski RE, Shibata DK, Bernal B, Zurakowski D, Comstock B, Jarvik JG. Interrater reliability in assessing quality of diagnostic accuracy studies using the QUADAS tool. A preliminary assessment. Acad Radiol. 2006 Jul;13(7):803-10. PubMed PMID: 16777553.

49.         Trout AT, Kallmes DF, Gray LA, Goodnature BA, Everson SL, Comstock BA, Jarvik JG. Evaluation of vertebroplasty with a validated outcome measure: the Roland-Morris Disability Questionnaire. AJNR Am J Neuroradiol. 2005 Nov-Dec;26(10):2652-7. PubMed PMID: 16286418.