CAUSES OF HEPATOMEGALY IN CHILDREN

I. Infectious/Inflammatory:

  1. TORCH infections
  2. Viral hepatitides (all)
  3. Hepatic abcess
  4. Visc. larval migrans, schistosomiasis, liver flukes
  5. Toxins, drugs
  6. Biliary obstruction

II. Congestive

  1. Cirrhosis/Wilson's
  2. Stenosed/thrombosed portal/splenic v.
  3. Myeloid metaplasia
  4. Vinyl chloride
  5. Biliary atresia
  6. CHF (right-sided)

III. Storage

  1. Glycogen storage diseases
  2. GAG-oses
  3. Gaucher's
  4. Neimann-Pick's d.
  5. Porphyrias
  6. Amyloid
  7. Wilson's

IV. Infiltrative

  1. Erythroblastosis fetalis
  2. Metastatic Ca
  3. Histiocytosis
  4. Leukemia, lymphoma
  5. Hepatoma
  6. Hepatic hematopoiesis
  7. Hemochromatosis
  8. Amyloid

V. Intrinsic hepatic dis.

  1. Cirrhosis
  2. Cong. hepatic fibrosis
  3. Multicystic liver/kidney dis.
  4. Hereditary hemorrhagic telangiectasia

VI. Kuppfer cell proliferation

  1. Sepsis
  2. Granulomatous hepatitis
  3. Hypervitaminosis A