TREATMENT OF CERVICAL CANCER
Adding chemo to traditional XRT improves outcomes in locally
advanced cervical Ca:
- 369 women with Ca confined to the cervix tx'd randomized
to cisplatin vs. no cisplatin; all got pelvic irradiation
then hysterectomy; cisplatin group had RR 0.5 for disease
progression or death over avg. 3y f/u (NEJM 340:1154,
1999--JW)
- 526 women with locally advanced cervical Ca randomized to
cisplatin vs.cisplatin + fluorouracil + hydroxyuria vs.
hydroxyurea alone; all got radiotherapy; rates of overall
survival and progression-free survival was sig. higher in
both cisplatin groups (NEJM 340:1144, 1999--JW)
- 403 women with advanced cervical Ca confined to the
pelvis randomized to cisplatin + fluorouracil vs. no
chemo; all got pelvic irradiation; at 5y, chemo group had
sig. higher overall and disease-free survival rates (73%
vs. 58% and 67% vs. 40%, respectively) (NEJM 340:1137,
1999--JW)