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Phosphate regulates cementum (cem) formation. I.Development: control
of PPi/Pi locally is critical for development of a functional periodontium.
Absence of Pi (TNAP null, hypophosphatasia) results in minimal cementum
formation with exfoliation of teeth, in humans. In contrast, lack of
PPi appears to favor cementum formation, e.g. ank mutant mice, with normal
development of the PDL and bone. II. Regeneration: We predict
that controlling the ratio of PPi/Pi locally in favor of |
Pi
during regenerative procedures,
will