1. Expression of Attachment Proteins During Cementogenesis (NIH/NIDCR)

• Specific Aim 1: To determine the role of amelogenin in regulating development of the periodontium.
• Specific Aim 2: To define the role of BMP2 and BMP3 in cementogenesis.
  
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2. Key Modulators of Cementogenesis (NIH/NIDCR)

• Specific Aim 1: To determine the role of ANK in cementum formation.
• Specific Aim 2: To establish the mechanisms by which phosphate regulates formation of root cementum.
• Specific Aim 3: To prove that increasing local levels of Pi and/or decreasing levels of PPi at periodontal wound healing sites will result in promoting cementum formation and subsequently new bone and a functional PDL.
  
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3. Potential Mitigating Factors for Feline Osteoclastic Resorptive Lesions (FORL) (Private Funding)

• Specific Aim 1: To determine the effects of phosphate salts (specific
  nutrients) on cells associated with the local tooth environment.
• Specific Aim 2: To determine whether or not crevicular fluids obtained from cats with FORL have a different composition compared with cats without such lesions.
• Specific Aim 3: To determine whether or not sera obtained from cats with FORL exhibit different properties when compared with normal cat sera.
  
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